The Science of SuperShot
The Most Complete PRP.
SuperShot PRP® uses a patented aqueous two-phase system to create an extracellular vesicle rich PRP at point of care.
For Physicians
For Patients
The Problem
Standard PRP throws away half the therapy.
In a standard PRP preparation, the platelet-poor plasma (PPP) is typically discarded — but it's rich in low-density extracellular vesicles, including exosomes, that transport proteins and microRNAs to support tissue regeneration, healing, and rejuvenation.
Standard PRP
✗Platelet-Poor Plasma → discarded
✓Platelet-Rich Plasma retained
✗Extracellular Fraction → not concentrated
SuperShot PRP® Aqueous Two-Phase System
✓PPP + SuperShot PRP® solution → 1-min spin
✓Extracellular Fraction → added to PRP
✓Zero waste
The Solution
Change the physics, not the protocol.
SuperShot PRP® uses a density gradient centrifugation solution to create an aqueous two-phase system that reduces the solubility of low-density lipoproteins — pelleting EVs at ordinary tabletop centrifuge speeds in just one minute. The result - a revolutionary EV rich PRP.
Fully Autologous
SuperShot PRP® concentrates what's already in the patient's blood — the same principle as concentrating platelets. Patient's own biology, zero foreign materials.
One Extra Minute
EVs can be pelleted at ordinary tabletop centrifuge speeds. The pelleted fraction is added back to your PRP. No new equipment required.
EV-Rich PRP
The result is PRP rich with Extracellular Vesicles — including exosomes — delivering the signaling molecules that can support regeneration.
By the Numbers
A measurable, reproducible enrichment.
Independent analysis via NanoSight particle tracking and Illumina single-end RNA sequencing.
845B
Extracellular Particles
Unique extracellular particles isolated from 5cc of plasma (169B/mL) with average 130nm diameter.
166×
More Than Allogeneic Exosomes
The leading allogeneic MSC exosome product contained just 0.6% of the EVs isolated by SuperShot PRP® from 5cc of plasma.
↑ miRNAs
microRNAs Enriched
Key signaling microRNAs that effect pathways of angiogenesis, cellular proliferation, and protein synthesis etc are captured.
Peer-Reviewed Research
The growing evidence for plasma exosomes.
Extracellular vesicles and the microRNAs they carry are an active frontier in regenerative medicine.
Muscle Regeneration
Exosomes from PRP and MSCs promote recovery of function after muscle injury
PubMed →
Cardiac Protection
Plasma exosomes protect the myocardium from ischemia-reperfusion injury
PubMed →
Wound Healing
PRP-derived exosomes promote re-epithelialization of chronic cutaneous wounds via YAP activation
PubMed →
Radiation Wounds
Plasma-derived exosomes boost healing of irradiated wounds via cell proliferation and ferroptosis
PubMed →
Bone Preservation
PRP-derived exosomes prevent glucocorticoid-induced apoptosis in osteonecrosis of the femoral head
PubMed →
Stem Cell Support
SuperShot PRP® EF stimulates Mesenchymal Stem Cell growth 2.4× over control in 5-day culture
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Regulatory Status
SuperShot PRP® is an FDA 510(k) cleared device for the safe, rapid preparation of autologous platelet-rich plasma from a small sample of the patient's own blood.
Blood product per FDA guidance (July 2020, Section V.A)
Fully autologous — patient's own biology
Collected and delivered in a single surgical procedure
No allogeneic or xeno-sourced materials